Lymphatic and blood vasculature in primary cutaneous melanomas of the scalp and neck.

نویسندگان

  • Sandro Pasquali
  • Maria Cristina Montesco
  • Chiara Ginanneschi
  • Gianna Baroni
  • Clelia Miracco
  • Carmelo Urso
  • Fabio Mele
  • Anna Rita Lombardi
  • Pietro Quaglino
  • Laura Cattaneo
  • Stefania Staibano
  • Gerardo Botti
  • Paolo Visca
  • Marina Zannoni
  • Giuseppe Soda
  • Barbara Corti
  • Luca Pilloni
  • Luca Anselmi
  • Amelia Lissia
  • Margherita Vannucchi
  • Cristina Manieli
  • Daniela Massi
چکیده

BACKGROUND Scalp/neck melanomas have a poor prognosis, possibly because of a rich vascular supply that prompts tumor cells' dissemination. METHODS We compared the accuracy of immunohistochemical (IHC) staining with morphology for the identification of lymphovascular invasion in 156 scalp/neck melanomas. We then analyzed the association of vessel invasion and density with pathological features and survival. RESULTS IHC-detected lymphatic vessel invasion (LVI) and blood vessel invasion (BVI) were identified in 34.6% and 13.5% of cases, respectively. IHC increased the LVI/BVI detection compared to morphology (40.4% vs 16.6%; p < .001). The degree of peritumoral and intratumoral blood vessel density (BVD) was greater than lymphatic vessel density (LVD). Ulceration was the only factor independently associated with intratumoral (p = .029) and peritumoral (p = .047) BVD. Tumor thickness was the only independent predictor of survival (p = .002). CONCLUSION IHC allows accurate assessment of lymphovascular invasion in scalp/neck melanomas. In these tumors, we observed a high incidence of BVI, which deserves further investigations.

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عنوان ژورنال:
  • Head & neck

دوره 37 11  شماره 

صفحات  -

تاریخ انتشار 2015